Could a unique new fungus offer an opioid alternative?

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A new fungus discovered in the estuarine waters of Tasmania could be the unexpected answer to the world’s opioid crisis, a current study suggests.

A fungus present in Tasmanian estuarine water may yield an effective and safe opioid alternative.

Opioids many of which are prescription painkillers, such as codeine  have created a worldwide health crisis. Many opioids are highly addictive substances that some people overuse or misuse.

According to data from the National Institute on Drug Abuse, over 130 people die each day in the United States because of an opioid overdose.

The Health Resources and Services Administration call this “an unprecedented opioid epidemic.” The situation has led to the World Health Organization (WHO) encouraging countries to monitor the use of opioid drugs closely.

But while monitoring the use of opioids is helpful, scientists are on the lookout for opioid alternatives. They are searching for drugs that will treat chronic pain in the same way as opioids but are less likely to harm health or lead to misuse.

A novel discovery by researchers from the University of Sydney in Australia — in collaboration with colleagues from other academic institutions — may, in the future, lead to the development of one such potent alternative.

The team found an unknown species of the fungus Penicillium in an estuary in the Huon Valley in Tasmania. The researchers showed that this fungus contained a set of molecules called “tetrapeptides,” which are amino acids.

These molecules had a unique structure that emulates the shape of endomorphins, which are natural opioid chemical messengers that help deliver pain relief.

The team notes that these new fungus-derived tetrapeptides have the potential to cause fewer side effects than regular opioids, while still delivering effective pain relief.

A ‘never-before-seen’ molecular structure

Senior author Prof. Macdonald Christie and colleagues explain that the newly discovered fungus yielded three different versions of tetrapeptides — with a very interesting and unexpected molecular structure.

More specifically, the team found that these fungus-derived molecules had a surprising chirality, or “handedness,” which refers to the geometric orientation of the molecular structure.

Some molecules have a geometric property that means they can have a “left handed” or a “right handed” structure, the two of which are mirror images of each other.

Moreover, their orientation can make a significant difference, since it will determine how a molecule “fits” or reacts with other molecules that it interacts with.

In nature, most amino acids display “left handedness,” and while there are some exceptions, the amino acids present in mammals are very rarely “right handed.”

This is important because, as the researchers explain in their paper  which appears in the journal PNAS — recent studies have emphasized the importance of peptides (short-chain amino acids) of mammalian origin in the context of developing new and better alternatives to traditional opioids.

The tetrapeptides present in the newly discovered Penicillium are special precisely because they display “right handedness.” This unusual chirality allowed the researchers to determine these molecules’ properties and the fact that they were a promising alternative to opiates.

“No one had ever pulled anything out of nature, anything more ancient than a vertebrate that seemed to act on opiate receptors — and we found it,” says Prof. Christie.

The structure we found has never been seen before.”

Prof. Macdonald Christie

The team has already filed a patent application in Australia and continues the research, aiming to confirm whether the newly discovered molecules can lead to the development of a novel drug.

However, Prof. Christie cautions that even if they do get their confirmation and begin further tests, it could be another 10 years until the new pain reliever becomes commercially available.

Yet, he emphasizes, “[i]f this proves successful and leads to a new medication, it will significantly reduce the risk of death by overdose from opioid medications, such as codeine.”

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2 thoughts on “Could a unique new fungus offer an opioid alternative?

  1. Not interested in a 10 years from now Tasmanian river fungus. Poppies grow EVERYWHERE and the OPIATES could not be MORE Perfect. Granted UN-IDIOTING most of the healthy public holds out about as much hope.

    1. We’ve known for numerous decades now what would significantly reduce (likely eliminate) the risk of death by overdose from opioid medications. Simply getting drug addicts to stop injecting themselves with illicit heroin, and/or illicit heroin laced with illicit fentanyl.

      Because virtually nobody ever overdoses on legally prescribed opioid medications if they take them as prescribed. Yet, addicts have been, and will most assuredly continue to overdose on illicit heroin and fentanyl, or a combination thereof up until the time the clueless/corrupt government figure that out, nothing whatsoever is going to change.

      As been clearly evidenced from the previous 3-years of ever-increasing overdose fatalities, persecuting & harassing innocent pain patients and their physicians is only going to cause more & more overdoses.

      But, what the heck, let’s continue to knowingly kill thousands of our own innocent citizens (year-after-year) to further demonstrate the power of our government’s ignorance.

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